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Ecotoxicol Environ Saf 188:109935
These superoxides can oxidize thioredoxins and detach the apoptosis signal-regulating kinase 1 (ASK-1) from them, thus triggering the self-activation of ASK-1

Tan Z, et al

However, for some people with epilepsy, high doses of caffeine or other stimulants can lower the seizure threshold, making them more susceptible to seizures[224]
