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With their assistance, cystine is absorbed into cells and rapidly reduced to cysteine, participating in the synthesis of intracellular GSH (Ingold et al., 2018

FIGURE 7 4.5 Multimodal synergistic therapy As mentioned above, we clearly recognize that GSH-responsive and -exhausting metal nanomedicines have a prominent effect on cancer therapy

Nat Commun 4(1):2192 Mason H, Rai G, Kozyr A, De Jonge N, Gliniewicz E, Berg LJ, Wald G, Dorrier C, Henderson MJ, Zakharov A, Dyson T (2023) Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

This response element is referred to as the DR5 element