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BLAST analysis generated multiple hits based on the methyltransferase domain (pfam 13847: corresponding to residues 175283 of RIPS-1)

329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes

It provides the primary nutrients known to be necessary for the breakdown of homocysteine into methionine and other metabolites, including vitamin B6 as pyridoxine and pyridoxal-5-phosphate (P5P), vitamin B12 as methylcobalamin, folate as 5-methyltetrahydrofolate (5-MTHF), trimethylglycine (TMG), and L-serine.* It is now enhanced with vitamin B2 as riboflavin-5-phosphate, Setria glutathione, zinc, and increased amounts of activated pyridoxal-5-phosphate.* Recommendation: Allergy Research Group suggests taking 1 capsule one or two times daily with meals, or as directed by a healthcare practitioner