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Under oxidative stress, excessive ROS such as OH directly attack DNA, causing single-strand or double-strand breaks, activating PARP-1, consuming NAD and ATP, and generating poly(ADP-ribose), resulting in mitochondrial membrane potential loss and the release of apoptosis-inducing factor, ultimately resulting in cell death [252]

NGF plays an important role in the pathogenesis of depressive symptoms and the response to antidepressant treatment, which can be seen from that exogenous NGF could induce antidepressant-like effects in rodent depression models (Wiener et al., 2015)

Previous studies on the OM of unsaturated fatty acids, esters, or lipids have primarily focused on industrial applications [3, 18, 19], employing conditions such as thermodynamic sinks, elevated temperatures, aprotic organic solvents, and neat solutions to achieve high substrate conversions up to 100% with 0.1 mol% catalyst [20,21,22,23,24,25]

S., Mukhopadhyay, A., Bachmaier, K., Shin, J