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60-180
Continue isotretinoin until the patient is clinically clear for two months before stopping treatment and aim for a higher cumulative dose to minimize acne relapse
69, 70 Certain sets of circulating microRNAs might function as a tumor surveillance mechanism exerting continuous inhibition on tumor formation
However: Metformin: Long-term metformin use can deplete B12, making Lipo-C supplementation potentially beneficial
