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Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants Profound sedation, respiratory depression, coma, and death may result from the concomitant use of oxycodone and acetaminophen tablets with benzodiazepines and/or other CNS depressants, including alcohol (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids, [gabapentin or pregabalin] and other opioids)

[DOI] [PMC free article] [PubMed] [Google Scholar] 436.Tezuka D., Kawamata A., Kato H., Saburi W., Mori H., Imai R

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