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In addition to PHGDH, serine hydroxymethyltransferase (SHMT) is also implicated in tumorigenesis
MTORC1 expands Th17 and IL-4 + DN T cells and contracts Tregs in SLE
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However, in contrast to healthy rats showing sustained increases in GFR and RPF during treatment with bGH and rhIGF-1, no significant effects of these measures on GFR, RPF or filtration fraction were noted in 5/6 nephrectomized rats
