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Expression microarray and quantitative PCR analysis identified circFRMD4A as a p53-regulated circular RNA that is induced by DNA damage stress (5-FU/cisplatin) and MDM2 inhibitors (nutlin-3 and APG-115) in wild-type p53 (wtp53)-harboring cancer cells
In this context, melatonin acts as an inhibitor or stimulator of proteins (Period 1 and Period 2) that control the transcription and expression of other genes responsible for most of the cellular circadian functions [6,22,26]
Gherardi, E
M.TozoniS
