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These genetic insights may help provide context for why certain individuals show robust response to triple-agonist therapy while others require dose adjustment or alternative approaches
2021;143 doi: 10.1016/j.biopha.2021.112139.112139 [DOI] [PubMed] [Google Scholar] 155.Rahimi M

Although DAAs offer the chance of viral cure for most of HCV patients, there are some limitations that restrain their full potential, including their high cost limiting access to treatment, the high mutation rate of HCV which may lead to the selection of DAA-resistant HCV variants resulting in treatment failure, and the low SVR rate in difficult-to-treat patients such as those with advanced liver cirrhosis [12, 13, 14]
