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Vitamin B12 is the most chemically complex of all the vitamins, and cyanocobalamin and hydroxycobalamin are synthetically derived therapeutic forms of vitamin B12.6 Hydroxycobalamin protein binding capacity is greater than that of cyanocobalamin and both of them may cause allergic reactions.6 Vitamin B12 may lead to allergic reactions because of its cobalt molecule, molecular complexity or high molecular mass

Pyridoxine and Methylcobalamin are generally considered safe in pregnancy when used appropriately, but medical supervision is essential

In persons with intestinal lesions such as jejunal diverticulosis or some anatomical abnormalities with bacterial overgrowth (e.g., fistulas and blind-loops), vitamin B12 deficiency may develop because bacteria in the colon competitively utilize all the available vitamin B12 (Cooke et al., 1963)