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The inotropic effect is augmented by caffeines inhibition of phosphodiesterase, which increases the concentration of cAMP in the myocardium and enhances the intracellular influx of calcium ions into cardiomyocytes
Based on limited human pharmacology data, ipamorelin appears relatively selective, with less pronounced effects on cortisol and prolactin secretion compared with some other GH secretagogues though this selectivity has not been extensively validated in large human trials
Prade et al., 1998)
