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Figure 4 confirms that there is indeed a hydride transfer equilibrium between the NADPH and the FAD cofactor in that complete exchange of the NADPH dihydronicotinamide Pro-S hydrogen is observed in buffered deuterium oxide in the presence of catalytic amounts of SmTGR C159S

Overall, DMSA therapy in this study seemed relatively safe, with only a few reports of adverse effects that were generally temporary and of mild or moderate severity

The sections were stained with lead citrate (10 min) and methanolic uranyl acetate (20 min), with thorough ddHO washing between staining steps

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