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Globally, 500 million to 1 billion people are affected by selenium deficiency Diets low in fresh, whole foods are often insufficient in selenium Certain conditions, including phenylketonuria , can increase the risk of deficiency Some people may also have higher needs due to inflammation, metabolic stress, or nutrient absorption issues Deficiency may go unnoticed for a while, but its effects can ripple across hormonal systems, immune regulation, and sexual vitality

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Manganese ion supplementation promotes glucose uptake in HD-model cells by enhancing insulin/IGF receptor-induced AKT signal (Bryan et al

Nature 504 , 446450 (2013)