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[27,62] The pineal hormone has been proven to have beneficial effects in the treatment of obesity-related characteristics, including a decrease in the adipocyte secretion of TNF- and IL-6, an increase in high-density lipoprotein cholesterol, a reduction in visceral fat, and a reduction of plasma levels of triglyceride, low-density lipoproteins, very-low-density lipoprotein cholesterol

Additionally, a meta-analysis reveals that Spirulina significantly reduces total cholesterol, LDL-cholesterol, and triglyceride levels while increasing HDL-cholesterol levels

Studies demonstrated that dapagliflozin reduces renal tubulointerstitial fibrosis and inflammation by attenuating the production of reactive oxygen species and inflammation production [27]