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Given that bacterial products such as TLR agonists or metabolites such as SCFAs are capable of potentially traversing the placental barrier to reach the fetus, it is plausible that the maternal gut microbiome can influence the development of fetal epithelium and immune cells, even in the absence of live bacterial colonization in the fetal gut (Sanidad and Zeng, 2020)

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10.1016/j.jep.2007.09.017 124 SinghalV.BoraD.SinghS

Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity