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Some MTHFR variants with significant hypomethylation are theoretically capable of developing either low flow POTS or high flow MCAS type POTS

doi: 10.1002/med.21511

Although our skin is durable and exceptionally flexible, when it expands in a short amount of time, it results in tears, otherwise known as stretch marks

Further, diminished growth factor signaling under these conditions significantly attenuates cellular proliferation (154)
