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The most common symptom is pain and swelling in the big toe, but it can also affect other joints in the foot, ankle, and knee

The ATP- and UTP-binding pockets located on the concave surface of PyrG are defined by residues from two and three adjacent subunits, respectively (Fig

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For example, the terms acylamino and alkylamino refer to specific N-substituted organic radicals with acyl and alkyl substituent groups respectively