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Folate deficiency accelerates Alzheimers disease related pathology in APP/PS1 mice

By mediating the transcription of crucial antioxidative enzymes, FOXO4 may help mitigate oxidative stress and maintain cellular integrity and function during episodes of high oxidative load or inflammation

Pre-treatment of cells with membrane-permeable inorganic or organic polysulfides, confirmed to generate endogenous GSSH (Extended Data Fig

4.2 Regulation of signaling pathways by MTH1 In a separate study focusing on non-small cell lung cancer (NSCLC), it was discovered that MTH1 not only promotes the progression of NSCLC but also enhances activities in the MAPK pathway and PI3K/AKT in cancer cells