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The Transsulfuration Connection: MTHFR, Cysteine, and Glutathione Substrate Glutathione synthesis requires cysteine as its limiting amino acid substrate not methionine directly, but the cysteine produced from methionine through the transsulfuration pathway (methionine SAH homocysteine cystathionine cysteine, catalyzed by CBS and CTH)

[DOI] [PubMed] [Google Scholar] 56.Shi Z.Z., Osei-Frimpong J., Kala G., Kala S.V., Barrios R.J., Habib G.M., Lukin D.J., Danney C.M., Matzuk M.M., Lieberman M.W

The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells