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A clinical study has shown an association between increased oxidative stress and renal proximal tubular cell injury in CKD patients with proteinuria (Nishi et al., 2013)

M1 microglia release neurotoxic and inflammatory factors such as IL-6, IL-1, and TNF-, contributing to neuronal damage and death, while M2 microglia secrete neurotrophic factors including BDNF, IL-4, and IL-10, fostering neuronal growth and protection (51)

Abstract Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and plasticity of Central Nervous System (CNS) synapses

Recent advancements have introduced alternative extraction methods, such as microwave-assisted, ultrasonic, and enzyme-assisted techniques, which have addressed some of these limitations to varying degrees