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Acknowledgments We are grateful to Yao Yao and Xin Bin from the Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong for assisting in assembly of figures and tables and reference organization

Rats treated with CS and Fe 3 O 4 did not demonstrate significant changes in MDA (F (2,15) = 0.017) and GPx (F (2,15) = 2.230) levels compared to the CCl 4 group

Additionally, the traditional Chinese medicine compound Qingre Huayu Jianpi decoction has been demonstrated in colorectal cancer studies to effectively inhibit the activation and migration of CAFs, reduce the deposition of ECM components such as collagen, and suppress the growth of tumor organoids by regulating the Wnt/catenin pathway