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AP-1 and NF-B induce the expression of multiple genes involved in inflammation and oxidative stress response, cell death and fibrosis, including proinflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 and interleukin-6 and growth factors such as PDGF and TGF-

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[183] [184] The discovery of leptin also is documented in a series of books including Fat: Fighting the Obesity Epidemic by Robert Pool, [185] The Hungry Gene by Ellen Ruppel Shell, and Rethinking Thin: The New Science of Weight Loss and the Myths and Realities of Dieting by Gina Kolata

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