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The efficacy of the checkpoint inhibitor immunotherapy is augmented in the presence of Bifidobacterium and Bacillus fragilis through the shaping of the host immune system (145, 146)

In particular, BHB, in addition to its role as an energy source, also has a variety of molecular signaling and regulatory functions in a wide range of human diseases ( 4.1 Epigenetic regulation BHB has been reported as a Class I histone deacetylase (HDAC) inhibitor and an endogenous neuroprotective epigenetic modifier ( 4.2 Gut microbiome Gut microbes are also known to be involved in the development of many diseases