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10.1007/s00701-019-03868-7 16 DrmicD.KolencD.IlicS.BaukL.SeverM.Zenko SeverA.et al (2017)
the B12 supports energy levels during caloric deficit but does not change tirzepatide's pharmacology

Filipsson, H

Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified