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It acts by stimulating orexinergic neurons, which subsequently promotes wakefulness while inhibiting both the non-rapid eye movement (NREM) and rapid eye movement (REM) sleep stages.27 N-methyl-D-aspartic acid (NMDA), a naturally occurring amino acid derivative in animal organisms, functions as a homologue of L-glutamate and serves as a key excitatory neurotransmitter receptor agonist in the central nervous system

At the transcriptional level, the larval PNCs possessed 1390 upregulated and 1388 downregulated genes, relative to PNCs from 1-week-old adult animals (Fig

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