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8.4 Others According to studies, the main target of novel asthma medications can be T-helper type 2 (Th2) cytokines

doi: 10.1007/s00109-023-02414-4 68 GuoJMaYTangTBianZLiQTangLet al

Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible

Second, proteostasis disruption involves declined autophagylysosomal and ubiquitinproteasome activity, rendering proteins like syn prone to aggregation and resistant to clearance [62]