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ACE'10: Proceedings of the 9th WSEAS International Conference on Applications of Computer Engineering

In a murine model of B16F10 melanoma expressing both VEGF-C and chicken ovalbumin (OVA), overexpression of VEGF-C in cancer cells promotes lymphangiogenesis in both primary tumors and TDLNs, leads to CD8+ T cell immune tolerance via LEC cross-presentation ( Figure 1 ), protects tumors against preexisting anti-cancer immunity, and promotes the local elimination of OVA-specific CD8+ T cells (93)

doi: 10.3322/caac.21660 5 LlovetJMKelleyRKVillanuevaASingalAGPikarskyERoayaieSet al

Metabotropic glutamate receptors and neurodegenerative diseases
