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--- The Clinical Frontier The strongest human evidence now supports: Metformin (metabolic reprogramming) NAD boosters (mitochondrial repair) MSC infusions & TPE (cellular rejuvenation) GLP-1 agonists (metabolic efficiency) The future lies in combination strategies integrating metabolism, cellular repair, and mitochondrial support for multimodal rejuvenation

doi: 10.1074/jbc.M206835200, [DOI] [PubMed] [Google Scholar] Ge D., Noakes P

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[128] explored the interaction between ALA (50 mg/kg IV) and valproate (50 mg/kg IV) in rats, finding that ALA increased the AUC 06 h for valproate