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Melatonin administration from 0.3 mg to 5.0 mg has been shown to exert a sedative-like effect.* When supplemented prior to the onset of the body's normal melatonin secretion, even a low amount of melatonin can promote sleep.* Melatonin apparently enhances the effect of gamma-aminobutyric acid (GABA) via direct interaction with GABA receptors, thus resulting in relaxation.* Thorne's Melaton-3 supplies three mg of melatonin in each capsule, and Melaton-5 supplies 5 mg per capsule and is used when a higher amount of melatonin is desired. Melatonin also has significant antioxidant activity.* Adequate melatonin levels have been reported to be a positive factor in cardiovascular, neuroendocrine, GI, and bone health.*

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Only melanoma-in-situ has adequate evidence to support surgical excision