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The NOAEL for these effects was 125 mg -tocopheryl acetate/kg body weight (Abdo et al., 1986)
In addition, de novo l-serine synthesis from glucose is coupled to l-glutamate availability and -ketoglutarate, and this relationship has been hypothesized to influence tumorigenesis upon genomic PHGDH amplification (93)
& Katagiri, G
While each system detoxifies specific peroxides via GPx or Prx, they share substrates and can compensate for one another when impaired
