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When activated, mast cells release a cascade of inflammatory mediators, including: This can disrupt the BBB, promote leukocyte infiltration, and create a pro-inflammatory CNS microenvironment

In some cases, injection near the affected tissue may be considered

Peptides offer alternatives to prolonged rest, NSAIDs, or premature corticosteroid injections that can weaken tissues

Cannabis has been used in many other chronic pain conditions and although legal aspects to conducting research with cannabis contribute to the lack of robust studies there is some exploratory evidence indicating it may be helpful for pain, depression, anxiety, sleep and inflammation [76,77,78,79,80,81,82]