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doi: 10.1126/scitranslmed.3002043

The legal status depends on where you are and how you're using it

Why creatine may help Reduces one major use of SAM-derived methyl groups Supports phosphocreatine and ATP buffering May be useful when SAM is low relative to methionine May support brain and muscle energy What creatine does not do It does not directly hydrolyze SAH It does not directly remove adenosine It does not correct kidney or liver impairment It does not replace treatment of oxidative or toxic burden Cystathionine, Transsulfuration and Glutathione Demand Homocysteine can be remethylated to methionine or enter the transsulfuration pathway

Opt for foods like mushrooms instead