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Nutrition, evolution and thyroid hormone levels a link to iodine deficiency disorders

Abstract The intestine plays an essential role in integrating immunity and nutrient digestion and absorption

It also helps reduce hunger signals in the brain, enabling individuals to naturally consume fewer calories without persistent cravings

The proposed mechanism involves direct interaction between the AEDG sequence and histones H1/3 and H1/6 a form of epigenetic regulation in which the peptide modulates chromatin accessibility at specific gene loci, thereby influencing transcriptional activity without altering the underlying DNA sequence (9)