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This is the fatty, insulating layer that wraps around nerve fibers (axons), much like the plastic coating on an electrical wire

SI can regulate the production of inflammatory cytokines (TNF-, IL-6 and IL-1) by targeting immune cells such as T cells, macrophages, and neutrophils, thereby impacting various pathways including the NF-B pathway, PI3K-Akt signaling pathway, toll-like receptor signaling pathway, chemokine signaling pathway, Jak-STAT signaling pathway, and nod-like receptor signaling pathway, ultimately exerting an anti-RA effect

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doi: 10.3389/fimmu.2020.01451