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Description
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Weeks 17 through 20: Increase to 12.5mg once weekly if 10mg is tolerated but additional weight loss is desired
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The results demonstrate that GSHee (100 mol/kg, IV) has pronounced positive effects on breathing in freely-moving adult male SpragueDawley rats and that it markedly attenuates the deleterious effects elicited by subsequent injection of fentanyl (75 g/kg, IV) on minute ventilation, A-a gradient and ABG chemistry while extending the analgesic actions of the OR agonist
