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To successfully integrate these markers into clinical practice, the primary focus should be on establishing Contexts of Use (COUs)formal statements that define the specific purpose and manner of biomarker application in drug development and clinical diagnosis (268)

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INP network analysis highlighted a more effective path: supplying precursors (L-cysteine, glycine, glutamate) along with N-acetylcysteine (NAC) and alpha-lipoic acid (ALA) which boost endogenous synthesis through -glutamyl cycle activation

(2013) on sugarcane mosaic virus (ScMV) reported a significant increase in GST activity in resistant sorghum cultivars