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Simultaneously, there is growing interest in refining modulation of the endocannabinoid system beyond plantderived cannabinoids, focusing on developing compounds that selectively target the cannabinoid Type 2 (CB2) receptor to potentially dampen neuroinflammation [422] or those that inhibit fatty acid amide hydrolase to boost levels of the endogenous cannabinoid anandamide [423], aiming for analgesic efficacy with a reduced psychoactive burden

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Lipone et al., 2020