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Nevertheless, although the differences in the metabolic states of M1 and M2 are well accepted, the underlying mechanisms involved in switching between metabolic states are not well understood

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Treatment that works for one person may differ from what works to treat someone else with the same condition

Further research is needed to develop new tools for diagnosing painful discs that require cell therapy, to develop alternative pathways to eliminate nociceptors growing in painful discs, to further understand the fate and action mechanism of transplanted cells, and to restore the mechanical environment of degenerate discs, so that cell therapy finally moves from the laboratory to the clinic