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Inflammation, oxidative stress, Ca 2+ dysregulation, and hypoxia can induce cellular endoplasmic reticulum stress (ERS) by overloading the ERs protein folding mechanism ( Some studies have found that ferroptosis and ERS share a common pathway, especially in tumor diseases, and disease trends can be altered by controlling the ERS or ferroptosis pathway ( 2 Ferroptosis in RA With the study of RA disease mechanisms, it has been found that the aberrant activation of RA-FLSs, destruction of articular cartilage, overactivation of immune cells, and sustained expression of inflammatory factors are associated with ferroptosis

10.1093/ije/dyw319 107

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A GWAS in male Chinese participants revealed four loci (MSX2, CXCR5, PRKCE and MARCKS) associated with the presence of tophi, introducing novel and currently insufficiently explored genetic associations with gout