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Studies have shown that electrophilic substances produced by oxidative stress are associated with a variety of diseases, such as cancer, Alzheimers disease, Parkinsons disease, schizophrenia, diabetes, atherosclerosis, and aging-related diseases [48,49,50,51,52,53,54]

IGF-1R is comprised of two alpha and two beta subunits linked by disulphide bonds

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