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Among the anti-inflammatory mechanisms, Hypericin significantly reduces the inflammatory response by inhibiting PKC and regulating the expression of various cytokines, including increasing anti-inflammatory cytokines like IL-4 and IL-10.6,52 Curcumin acts by blocking the NF-B pathway and inhibiting COX-2 enzyme activity, which helps reduce the production of pro-inflammatory cytokines and mediators.135 As for antioxidant activity, Hypericin scavenges free radicals by generating ROS through photoactivation
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Kath R, Gupta R
"The DNA methyltransferase DNMT3C protects male germ cells from transposon activity"
