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Nrf2 mitigates RANKL and M-CSF induced osteoclast differentiation via ROS-dependent mechanisms

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It stimulates Akt, ERK1/2 and P38 MAP kinase leading to Nrf2 phosphorylation and its import into the nucleus [202, 218]

This involves the development of targeted food-based interventions that contain specific hormetic agents, followed by rigorous testing of their efficacy and safety in human populations through well-designed clinical trials