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Fortunately, a recent change in the formulation has reduced the sulfur odor and skin irritability, allowing its use as a cream. Trial details The quasi-randomized, multicenter, evaluator-blinded clinical trial from Brazil was conducted between October 2019 and February 2020, involving 40 women representative of a Brazilian sample of melasma patients, all of whom had facial melasma with skin phototype II to V, and aged 30 to 55

Hum Genet

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10.1007/s11427-017-9047-4 110 ZhangZ.LaiD.WangL.YuP.ZhuL.GuoB.et al (2014)