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Glutathione depletion and/or the concentration ratio [GSH]/[GSSG] are also often used as an indicator of oxidative stress

doi: 10.1016/s0945-053x(03)00006-4

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Despite the unknown and complex origin of ALS, numerous reasons, including redox metals dys-homeostasis, overproduced oxidative stress, mitochondrial dysfunction, neuro-inflammation, and glutamate excitotoxicity are responsible for motor neuron loss 10,11,12,13