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Bupropion, a nonselective dopamine- and norepinephrine-reuptake inhibitor, is considered to reduce weight by stimulating hypothalamic POMC neurons

It is used to support fat metabolism and steady energy as part of a broader weight management plan, not as a standalone weight loss treatment

While the peptides lack of IGF-1 effects and glucose impact suggests minimal interaction potential, comprehensive medication review remains appropriate, particularly for drugs affecting metabolism or blood glucose