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819,848 Alphafold2-based modeling suggests that many families of COG0523 proteins follow the same pattern (Figure 44B), while others have additional elements of secondary structure inserted between the 4 and 5 strands (Figure 44C), and some have an additional -strand N-terminal to 1 (Figure 44D)

The activity of NMNAT1 is essential for axon survival because activity reduced mutants have no axon protection effect

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