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This was later detected on the cell surface upon analyzing the translational product of 21-exon MET proto-oncogene and was classified as a growth factor receptor of the tyrosine kinase family

The ECM has a crucial role in the release of the niche signals that are essential for stem cell fate 133 , which probably has implication for diseases such as cancer, in which cancer stem cells might also be using such ECM signals to promote their survival and growth

Recent studies indicate that while the incidence of PD is lower in younger individuals, there is a trend towards the development of the disease even in populations traditionally considered to be of lowered risk (Willis et al., 2022)

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