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B-Clear Study Group

Deletion of both TRX1 and TRX2 affects the cell cycle, prolonging S phase and shortening the G1 interval (Muller, 1991)

Both paracellular hyperpermeability [demonstrated by abnormal TJ expression and upregulation of myosin light chain kinase (MLCK) activity (86, 322324)] and transcellular hyperpermeability [represented by bacterial internalization to epithelia (325)] were documented in mucosal biopsies of patients with Crohn's disease and UC

In clinical studies, therapeutic plasma exchange reduced 28-day mortality by 20.5% in severe sepsis patients, while other extracorporeal techniques, such as high-volume hemofiltration and hemoadsorption, showed significant reductions in inflammatory markers, though without consistent survival benefits [56]