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The reaction begins when methionine synthase takes a methyl group from active folate (5-methyltetrahydrofolate) and uses methylcobalamin to transfer that methyl group to a naturally occurring amino acid called homocysteine

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Pernicious anaemia , an autoimmune condition affecting approximately 2% of the UK population over 60 (and about 0.10.2% overall), destroys gastric parietal cells, eliminating intrinsic factor production and severely impairing B12 absorption

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