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Examples of Bayesianbased study designs that incorporate both toxicity and efficacy include the EffTox design46 or TriCRM.47 It is also important to consider the PK/PD relationship in elucidating a biologically active dose range as supported by the task force on Methodology for the Development of Innovative Cancer Therapies.48 What else can be considered
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Being informed and talking with your healthcare provider is the best way to make any decision
